Friday, May 12, 2017

Structure of H5NI virus

Viruses all have the same structure a core of genetic material (RNA or DNA) surrounded by a protein. The H5N1 virus, like all other influenza viruses, is an enveloped virus with an eight-segment single stranded RNA in the core and two surface proteins on the envelope, the hemagglutinin and the neuraminidase, which are responsible for the glycosilation, necessary for cell entry and exit.
H5N1 could be dangerous to humans; it is relatively easy to mutate into “H1N1-like” virus since their features of causing cytokine storm victims are same and their amino acid structure of glycoprotein are similar.

Scientists in California studied the structure and receptor specificity of the HA from an H5N1 influenza virus isolated in Vietnam in 2004 from a 10-year-old boy.

X-ray crystallography revealed that this HA had a number of features including receptor-binding sites, in common with HAs in typical H1N1 viruses that effect humans including the one that caused the 1918 pandemic.
Structure of H5NI virus
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