Thursday, October 13, 2016

Viral pathogenesis of influenza

Human influenza virus infection is characterized by striking contagious infection in the upper respiratory tracts i.e. flu syndrome accompanying systemic illness.

As in many infections, the pathogenesis of influenza is determined by a delicate balance of interactions between the host and pathogen. Free radical molecular species derived from the host have been a focus of considerable interest in study of viral pathogenesis.

Influenza viruses can produce a wide variety of pathological lesions in different organs of poultry and mammals. Based on morphological, cellular and biochemical evidences in various animal models, the virus exerts pathological effect by two mechanisms, viz. necrosis and apoptosis.

What is necrosis? Necrosis is the death of cells or body tissue while the body is still alive. This tissue death may affect the body systematically or the body may function normally while this process is going on. Necrosis is frequently involved in inflammation.

Apoptosis is a form of cell death based on sequential activation of ‘death genes’ and ’suicide pathway enzymes’. It is also called programmed cell death.

The tissue tropism of the influenza virus and tissue specific expression of virus receptors appears to play a pivotal role in pathogenesis.
Viral pathogenesis of influenza
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